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Notably, ferroptosis is characterized by lipid ROS accumulation (Guo et al., 2022) Therefore, we speculate that ferroptosis of OA chondrocytes may release a large amount of ROS into the blood circulation, increasing the level of serum oxidative stress, thereby disturbing the intestinal homeostasis and further exacerbating the pathological process of OA

10.3109/10799893.2015.1024851 164 KwakH

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week 2), pre-diet baseline symptom severity category (minimal/mild, moderate, or severe), and the challenge material * symptom severity category interaction